Immunoscintigraphy with monoclonal antibodies.

Monoclonal Antibodies

SUMMARY Monoclonal Antibodies are identical antibodies and Can be generated in ultimated amounts by countinuos cultures of single antibody- secreting cells. These cell lines are produced by cell fusion of normal lymphocytes to cells of a myeloma tumor cell line, which confers on the antibody producing hybrid cell, immortality and the ability grow as atumor in animals. monoclonal antibodies c...

Immunoscintigraphy of metastases with radiolabelled human antibodies.

Immunoscintigraphy of human tumors transplanted in nude mice with radiolabeled anti-ras p21 monoclonal antibodies.

Anti-ras p21 monoclonal antibody (RASK-3) was used for immunoscintigraphy of human cancer cell lines in nude mice. Iodine-125-labeled RASK-3 was injected into nude mice with either human colon cancers (FCC-1 or BM-314) or lung cancer (KNS-62). Clear images were obtained in all three cancers 7 days after the injection of antibody. No localization of 125I-labeled control monoclonal antibody was o...

Immunoscintigraphy and Radioimmunotherapy in Cuba: Experiences with Labeled Monoclonal Antibodies for Cancer Diagnosis and Treatment

INTRODUCTION The availability of monoclonal antibodies in Cuba has facilitated development and application of innovative techniques (immunoscintigraphy and radioimmunotherapy) for cancer diagnosis and treatment. OBJECTIVE Review immunoscintigraphy and radioimmunotherapy techniques and analyze their use in Cuba, based on the published literature. In this context, we describe the experience of Ha...

3245 Immunoscintigraphy with antimelanoma monoclonal antibodies in the diagnosis of choroidal melanomas

IMMUNOSCINTIGRAPHY WITH ANTIMELANOMA MONOCLONAL ANTIBODIES IN THE DIAGNOSIS OF CHOROIDAL MELANDMAS. LOCARNO C.M.? BALESTRAZZI AN. ,l FASOLINO G.f MANGANELLI C.l, GRECO I.M.? BLASI M.A.? CALCAGNI M.L.: AN0 GIOROANO A! 'DEPARTMENT OFOPHTHALMOLOGY, CATHOLIC UNIVERSITY OF ROME (I) 'DEPARTMENT OF EXPERIMENTAL MEDICINE, UNIVERSITY OF L'AQUILA (I) 3DEPARTMENT OF OPHTHALMOLOGY, UNIVERSITY OF L'AQUILA (...